The swelling and contraction of isolated rat-liver mitochondria
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The swelling and contraction of isolated rat-liver mitochondria.
In some pathological conditions there is an increase in the volume of the liver mitochondria. This condition, known as 'cloudy swelling', occurs in carbon tetrachloride poisoning and thyrotoxicosis (Bassi, 1960; Schulz, Low, Ernster & Sjostrand, 1956). Similar changes can be brought about in vitro by physiological concentrations of thyroxine (Tapley, Cooper & Lehninger, 1955; Tapley, 1956) and ...
متن کاملThe effect of thyroxine and other substances on the swelling of isolated rat liver mitochondria.
After the demonstration by Harris (1) that mitochondris in intact cells are sensitive to changes in osmolarity and the work of Claude (2) which showed that isolated mitochondria swell in hypotonic sucrose, a number of investigators (3-14) have studied the changes in water content produced when mitochondria are exposed in vitro to various media. In particular, Raaflaub (7-10) has investigated t,...
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A study was made of the effects of various types of detergents on the swelling of isolated mitochondria and on mitochondrial ATPases which are activated by Mg or DNP respectively. The rate of swelling was measured in the Beckman spectrophotometer by following the decrease in turbidity of dilute suspensions of these organelles. It was found that non-ionic detergents containing a nonyl phenoxy si...
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Through the use of combined spectrophotometric and electron microscope techniques, large amplitude swelling of rat liver mitochondria has been described as an ordered sequence of ultrastructural transitions. Prior to the actual swelling, mitochondria undergo two major conformational changes: condensed to twisted form and twisted to orthodox form. This sequence is independent of (a) the nature o...
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Mitochondria isolated from potato tubers fail to undergo passive osmotic swelling when suspended in isotonic Na(+) acetate or phosphate, in NaCl following addition of tripropyltin, or in Na(+) nitrate following addition of an uncoupler. Swelling under each of these conditions in mitochondria from other sources has been attributed to the inward movement of Na(+) on an endogenous Na(+)/H(+) excha...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1964
ISSN: 0006-2936
DOI: 10.1042/bj0930322